Content Uniformity Analysis by Transmission Raman Spectroscopy

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Sponsor

Content uniformity analysis would be benefitted by a rapid, non-destructive technique that is easy to use and quick to create a method – in contrast, for example, with traditional HPLC and NIR methods.  Transmission Raman spectroscopy (TRS) is an important emerging technique that offers significant resource and time savings in formulation development and QA/QC applications of solid dosage forms.

This webinar covers the benefits of TRS using examples and summarises the analytical advantages of quantitative TRS, including:

• Quantification of actives in solid dosage forms with high accuracy
• Rapid analysis (second(s)) per sample, even with multi-active mixtures
• No sample preparation – intact capsule and coated tablet analysis

Join the dedicated Transmission Raman Spectroscopy group at LinkedIn for more discussion and insight.

Presenter:

Professor Pavel Matousek Chief Scientific Officer Cobalt Light Systems

Pavel has worked at the Science and Technology Facilities Council's (STFC) Rutherford Appleton Laboratory in Oxfordshire since 1991. He pioneered the concepts of transmission Raman spectroscopy for pharmaceutical analysis and also Kerr gated fluorescence rejection from Raman spectra and Spatially Offset Raman Spectroscopy. Pavel has published over 160 peer reviewed articles and filed 10 patents. He is the recipient of 2009 Charles Mann Award for Applied Raman Spectroscopy from the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) and shares the 2002 and 2006 Meggers Awards from the Society for Applied Spectroscopy. Recently, he acted as the Chair of the Meggers Award Selection Committee and was elected as the Program Chair of FACSS 2011 (Reno, NV). Pavel serves on the Editorial and Editorial Advisory Boards of Applied Spectroscopy, Analyst and Journal of Raman Spectroscopy.

Pavel is an STFC Fellow, FRSC and a Visiting Professor of University College London.

About Cobalt Light Systems

Cobalt Light Systems develops products and technologies for non-invasive materials analysis. Our instruments have applications in many areas including pharmaceutical content testing, materials verification and security/counterfeit applications.  Our pioneering TRS100 instrument enables easy-to-use automated TRS analysis and was designed from the ground up for the heavily regulated pharmaceutical industry.  Other instruments for pharmaceutical analysis include a non-invasive raw materials verification tool which allows content ID through paper/plastic sacks, opaque plastic containers and coloured glass.  Cobalt’s instruments are also available for online implementation.

Cobalt is a spin-out from a UK research establishment and is based in Oxfordshire, UK.  For further information contact info@cobaltlight.com, +44 1235 433 200, http://www.cobaltlight.com/.
 

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Report Abuse   darren.andrews@cobaltlight.com 05/25/2011 10:22:35 AM EDT Transmission Raman works well in systems where the light scatters due to the turbid nature of the medium. Whether this is a powder, suspension or emulsion/cream the scattering will be significant. The compatibility with water is a particular benefit. We (Cobalt) have looked at several systems like this and would be happy to discuss further. Please use the contact details listed above or contact me directly at darren.andrews@cobaltlight.com. Replies (0) Post a reply Sign in or Sign up to post a comment

Report Abuse   aboushoer 04/12/2011 1:41:48 PM EDT Dears Thank you very much for lecturing on such an important issue. I would appreciate if you would be be to able to also comment on the applicability of such technique in non-solid pharmaceutical dosage forms (like suspensions, emulsions and creams) as it will also through some light on content uniformity within phase-uniformity. How such issue could reflect on nano-technology in poosting uniformity. Replies (0) Post a reply Sign in or Sign up to post a comment