Overcoming Common Lyophilization Scale-up Issues

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Topics covered in this seminar

-  Characterizing your systems (apparatus, containers, product) with a limited number of experiments and a simple procedure

-  Utilizing advanced monitoring tools to speed up the system characterisation process

-  Examining safe process transfer from one scale to another using either automatic control systems or a predictive modelling approach

-  Predicting changes in the design space in different pieces of equipment by means of process model, taking into account model uncertainty and confidence limits

-  Evaluating the distribution of product temperature, drying time, and residual water in your batch as a function of equipment design and operating conditions

-  Choosing the operating conditions that guarantee the required percentage of success for the product in hand

Presenter:

Antonello Barresi Dip. Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino

Antonello Barresi is a certified chemical engineer; he got a PhD in 1990 from the Politecnico di Torino. He has been visiting researcher at Yale (CT, USA), professor at the Addis Ababa University (Ethiopia) sent by the Foreign Office as part of International Cooperation program and “einsegnant invité” at the University of Lyon 1 (France) in 2000 and 2003.

Currently is full professor at Politecnico di Torino, teaching “Process design and development”, “Process control” and “Technologies for the food industry”.

His research activity (both experimental and modelling) concerned drying, mixing in homogeneous and multiphase systems, combustion (both catalytic and homogeneous). Main research interests in drying include: drying and freeze drying of pharmaceuticals and enzymes, lyophilization of food and damaged paper documents; development of new sensors and weighing devices for freeze driers; modelling and optimisation of freeze-drying, control of industrial freeze-dryers. The most recent research focused on developing new approaches for process development and quality control in freeze-drying of pharmaceutical products: in particular on minimisation of experimental activity in conjunction with use of modelling for obtainment of the design space, for recipe development and recipe scale-up, for process transfer.

Author of more than 120 papers on international journals, 20 contributions to edited book and book chapters, and more than 100 conference presentation.

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