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Melvin Evans:
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05/15/2011 1:24:25 AM EDT
Titrations, meaning increasing the amount/dose of the drug the patient is taking, takes place if desired effect not achievied with the original dose. Some doctors titrate to max dose before adding another drug, this practice makes sense if data shows that the max dose is the "most effective dose". Some drugs give you the biggest bang for the buck at "half max", so at that time it makes sense to add another drug. Also, the higher the dose, the higher the side effect potential. Many diseases, like diabetes and HPTN, the patient will get half max of one drug, and then doctor adds a second drug for a synergistic effect, or to get benefits of two different mechanisms of action.
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