Maria Wurm

CEO
ExcellGene

Check out the incredible speaker line-up to see who will be joining Maria.

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Day 2 - System Management

Wednesday, February 19th, 2020

9:10 AM Mini-Workshop

Disposable Bioreactors: Fluid Dynamics, Mixing, Shear Stress, Gas Transfer Rates – Insights for High-Density Cultures of CHO Cells

•Discuss the mechanical principals such as waving, rocking, stirring and shaking to provide homogeneity and oxygen transfers to CHO cells in disposable bioreactors

•Consider scalability and the capability of any of the systems to provide data at a small scale (mL to L) predicting the performance of the respective system at larger scale

•Uncover key insights obtained with different mixing approaches and discuss benefits and drawbacks of them for high-density cultures of CHO cells

Disposables Materials for Tox Protein Production: A Case Study for 0.5 Kg Manufacture

•Explore the steps required from cell thaw to manufacture and purification of > 500 grams of high-quality protein batch using exclusively disposable materials

•Highlight the importance of using pre-qualified materials from various providers

•Understand how integrating trained teams for use of the materials with no worries about sterility will reduce time lines significantly