The era of classical IgG molecules in bio pharma development is shifting rapidly to more challenging complex biopharmaceuticals. With CHO being a good production cell line for IgG molecules, they might fail to produce more challenging candidates. The GlycoExpress® (GEX®) system represents an ideal alternative for the production these difficult to express protein molecules.
Glycotope´s Service branch provides solutions for support the customers in their biopharma development program:
- Clone and process development in GlycoExpress® and rodent cell lines (USP Development, DSP development, analytical development)
- In depth PTM and protein analytics (N- and O-glycoprofiling, futher PTM e.g. deamidation and dxidation) which facilitates the clone identification process.
Additionally we provide
- Bioassay development services for different stages of drug development (Cell Viability & Cytotoxicity, Immuno-Oncology, Signaling, Cytokine Release Testing) and well as
- Clinical immunomonitoring service (Immunogenicity Assays, PK/PD Assessment, Biomarker Analysis)