The Trials and Tribulations of Comparator Sourcing for Clinical Trial Materials
The numbers of clinical trials that compare two active drugs, rather than testing a new drug against a placebo, are increasing. Comparator trials are chosen for two main reasons.
Firstly, there may be ethical reasons why using a placebo in place of a genuine treatment is not preferred. For example, if subjects have existing conditions that could worsen if their treatment is stopped for any period of time.
Secondly, there is a general increase in focus on the comparative effectiveness of...
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