Design, Conduct, and Analysis of Clinical Trials in Disease Due to Methicillin-Resistant Staphylococcus Aureus
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Given the changing epidemiology of disease due to Staphylococcus aureus (SA), including the emergence of drug-resistant organisms such as methicillin-resistant SA, investigators may wish to evaluatethe effects of antimicrobials in disease due to SA as well as in disease due to other organisms in the same trial. Here JH Powers and TR Fleming discuss issues that investigators should address in trial design, conduct, and analysisto evaluate overall effects or effects within subgroups according tocausative organisms.