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Joachim Tedroff, Head of Clinical Science at NeuroSearch Sweden AB, joins Helen Winsor from Pharma IQ, to discuss strategies for optimising clinical development in CNS. First Tedroff outlines what he sees as the major challenges in the development of CNS therapies coming onto the market. In the second part of the interview, he provides an update on NeuroSearch’s recent success with a Phase III clinical trial for Huntington’s Disease patients. He elaborates on the work underway and discusses whether this might open up therapeutic opportunities within Alzheimer's disease.