Buccal Delivery: Simple Physical Chemical Considerations
Efficient treatments options that are acceptable for both the patients and the physicians are the corner stones in drug development within the pharmaceutical industry.
Oral administration is the preferred route of administration as this route is normally associated with the highest patient compliance, what novel drug delivery systems must offer in particular better therapeutic outcomes compared to e.g. oral administration. One of these alternative delivery routes is oral transmucossal drug delivery – or just buccal delivery.
Buccal delivery has been explored intensively during the last decade to overcome the disadvantages of oral drug delivery. Absorption of the compound over the mucosal membrane includes bypass of first-pass metabolism and the avoidance of presystemic degradation in the gastro intestinal tract (1-3). Buccal delivery can be used for both systemic and local effects.
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