The Search for New and Innovative Excipients – Possible Applications of Semi Fluorinated Alkanes
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A high proportion of the drug compounds in the innovative pharmaceutical companies have poor aqueous solubility or high metabolic ratio (Fahr and Liu, 2007; Hauss, 2007; Lipinski et al., 1997), which may limit their bioavailability after oral administration. This provides the pharmaceutical scientist with a general challenge to identify enabling technologies or alternative delivery routes, which ensures sufficient exposure in order to market new, safer, and more effective drugs for the benefit...
