Steps to Expediting Time-to-Market for Insoluble Drug Candidates
Improving the solubility of new chemical entities has proven to be one of the biggest hurdles to overcome in pharmaceutical drug development, and companies are always looking for new strategies for increasing bioavailability of new drugs. Many companies are working to leverage new methods to measure, predict and improve drug solubility. However, understanding fundamental differences between thermodynamic and kinetic solubility is key for the development of drug candidates with improved solubility and suitable stability. Alphonso Higuera, PhD, Senior Research Scientist (Preformulation), Forest Research Institute explains....
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