Trends in Computational Toxicology & Critical Success Factors for Transporter Studies
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Trends in Computational Toxicology & Critical Success Factors for Transporter Studies
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In this exclusive interview Tobias Noeske, Associate Principal Scientist from AstraZeneca, speaks to Andrea Charles from Pharma IQ. Noeske describes how AstraZeneca are reducing compound attrition rates arising from drug-induced liver injury (DILI). DILI is a major cause for attrition in clinical trials, which can cost hundreds of million of dollars in the late stages of drug development.
Noeske explains how in silico models can identify and mitigate compound-related safet...
Tags:
BSEP inhibition
Tobias Noeske
computational toxicology
transporter studies
molecular physicochemical properties
AstraZeneca
salt export protein
drug transporters
clinically relevant drug transporters
