Oral Rotavirus Vaccines: How Well Will They Work




Rotavirus vaccines hold promise to decrease the burden of severe diarrhea in the poorest countries, where 85 percent of deaths due to rotavirus occur. However, the potency of live oral vaccines is lower in these challenging settings than in middle- and upper-income countries. Many hypotheses have been suggested to explain these differences that could provide clues to improve the ultimate success of these novel vaccines. Although introduction today of even moderately effective vaccines will decre...
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