Development of Drugs for Antimicrobial-Resistant Pathogens

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Clinicians have noted an association between antimicrobial resistance and antimicrobial use since the introduction of these agents over 50 years ago. The problem of resistance becomes more pressing, however, when organisms acquire resistance mechanisms to multiple antimicrobial agents. Treatment options are limited for some multidrug-resistant organisms. Antimicrobial resistance is a driving force for the need for new antimicrobial agents, especially for these multidrug-resistant pathogens. At the same time, large pharmaceutical companies have indicated that they are devoting fewer resources to antimicrobial drug development.