Whitepaper: Phys.- Chem. Characterisation of NCEs in Pre-Formulation: Use of In silico Tools
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As solubility (or rather poor solubility) is one of the hot topics in drug development, there is a strong interest in gaining solubility data early on, at a stage of a project where there is still a multitude of candidates investigated in parallel. So it is not surprising that there have been widely used approaches to calculate solubility in drug research, as well as doing the same for dissolution rate and more importantly bioavailability / in-vivo absorption during drug development.
This industry whitepaper highlights some rather practical considerations, used by Merck when looking into In-silico tools.
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