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In this interview Helen Winsor from Pharma IQ, speaks to lyophilisation expert, Michael Pikal, Professor of Pharmaceutics at the University of Connecticut, who has dedicated his life’s work to freeze drying. Pikal sheds light on this complex field, explaining just why lyophilisation is so difficult to get right, why the regulatory landscape is often misunderstood, how it can potentially be improved and how to achieve success in the lyophilisation process. Finally, looking ahead, he offers his opinion on whether the younger generation will be able to carry on the work of the few experts in freeze drying and whether he sees any advances in the pipeline.